Single-cell genomics
نویسندگان
چکیده
منابع مشابه
Single-Cell Genomics for Virology
Single-cell sequencing technologies, i.e., single cell analysis followed by deep sequencing investigate cellular heterogeneity in many biological settings. It was only in the past year that single-cell sequencing analyses has been applied in the field of virology, providing new ways to explore viral diversity and cell response to viral infection, which are summarized in the present review.
متن کاملFunction-driven single-cell genomics
Even prior to observing the great plate anomaly, one of the most enduring questions in microbial ecology has been, ‘who is there, and what are they doing?’. While we are still far from getting a true handle on microbial diversity on this planet, the ‘who’ has become easier to address, with the rise of environmental surveys of 16S ribosomal RNA sequences in the 1990s, allowing charting of commun...
متن کاملSingle-cell genomics: defining microbiology's dark matter.
We all remember this experiment from freshman biology: Take a sterile swab, rub it along the inside of your cheek, and transfer the collected microbes to a sterile agar plate. After incubating the plate overnight at 37 °C, the agar will be awash in bacterial colonies, a glossy and somewhat smelly testament to the fact that humans, fundamentally, are giant microbial buses. Yet that picture, it t...
متن کاملBarcode identification for single cell genomics
Single-cell sequencing experiments use short DNA barcode ‘tags’ to identify reads that originate from the same cell. In order to recover single-cell information from such experiments, reads must be grouped based on their barcode tag, a crucial processing step that precedes other computations. However, this step can be difficult due to high rates of mismatch and deletion errors that can afflict ...
متن کاملRecent progress in single-cell cancer genomics.
The advent of single-cell sequencing has been revolutionary to the field of cancer genomics. Perfectly suited to capture cancer's heterogeneous nature, single-cell analyses provide information bulk sequencing could never hope to uncover. Many mechanisms of cancer have yet to be fully understood, and single-cell approaches are showing promise in their abilities to uncover these mysteries. Here w...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Environmental Microbiology
سال: 2007
ISSN: 1462-2912,1462-2920
DOI: 10.1111/j.1462-2920.2006.01222_6.x